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Negative selection is a process that purges the mature T cell repertoire of self-reactive cells that would otherwise cause autoimmune disease. The expression of some, but not all tissue-specific proteins, are expressed on thymic medullary stromal cells through the gene called AIRE. This allows tissue-specific proteins from the periphery that would not otherwise be presented in the thymus to be presented to T cells.

If AIRE were defective, what would you predict to happen?

A

Selection of T cells would not be affected.

B

Negative selection of T cells would increase.

C

Negative selection of T cells would decrease.

D

Positive selection of T cells would decrease.

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