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Adaptive immune responses are initiated when B and T cells encounter antigens in the lymph nodes. For example, when a person is vaccinated by injecting vaccine antigen into the muscle of the arm, the vaccine antigen is able to activate B and T cells by entering the draining lymph nodes.

Which of the following is the predominant route by which the vaccine is brought from a site of injection into a lymph node?

A

Efferent lymphatics.

B

Arteries.

C

Veins.

D

Afferent lymphatics.

E

High endothelial venules (HEV).

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