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Apoptosis features prominently during T- and B-lymphocyte development. An estimated 95% to 98% of all thymocytes do not mature—most die by apoptosis within the thymus either because they fail to make a productive TCR gene rearrangement or because they fail to interact with self-MHC.

What makes apoptosis unique to other types of cellular death?


It allows for an inflammatory response that helps clear dead cells more efficiently.


Apoptosis is a form of necrosis.


Apoptotic cells dismantle their contents without disrupting their membranes, eliminating the release of any inflammatory inducing material.


Apoptosis does not activate caspases within the cell.

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