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Abatacept and Etanercept are two biologic therapies that can be used to treat rheumatoid arthritis patients. Abatacept (tradename Orencia) is a CTLA-fusion protein, whereby the extracellular domain of CTLA-4 is fused to the Fc portion of IgG1. Etanercept (trade name: Enbrel) is also a fusion protein, composed of the TNF-$\alpha$ receptor fused to the Fc portion of IgG1.

What is a serious side effect that would be predicted to be associated with BOTH of these therapies?


Reactivation of latent tuberculosis.


Increased incidence of severe infections.


Enhanced symptoms of type IV hypersensitivities.


Reactivation of latent herpes viruses.

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