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Which of the following genetic factors may contribute to the development of a Type I hypersensitivity response?

Select ALL that apply.

A

A mutation in the TIM gene family that regulates Th1/Th2 cell balance.

B

A mutation in MHC Class II genes allowing enhanced presentation of allergen-derived peptides.

C

A mutation in the IL-4 receptor that causes decreased signaling after ligation of the receptor.

D

A mutation in the beta 2-adrenergic receptor that increases bronchial hyperreactivity.

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