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The process of lymphocyte entry into lymph nodes occurs in four stages on High Endothelial Venules (HEV): rolling, activation, adhesion, and diapedesis. Each stage requires specific molecules including selectins, chemokines, and integrins.

From the choices below, select the process that is involved in the rolling of lymphocytes on HEV.

A

The integrin LFA-1 on T lymphocytes binds to ICAM1 or ICAM2 on high endothelial venules.

B

The selectin, CD62L or L-selectin, on T lymphocytes binds to the selectins, CD62P and CD62E (i.e., P and E selectins).

C

The chemokine, CCL21, bound on high endothelial venules activates integrins, such as LFA-1, on T lymphocytes.

D

The cell uses the chemokine receptor, CCR7, and the integrin, LFA-1, to traverse endothelial cells expressing CCL21 and ICAM1 or ICAM2.

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