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In order for leukocytes to signal to one another, such as in an antigen presenting cell presenting MHC:peptide complexes, they must interact intimately with surface bound receptors.

This interaction between leukocytes is referred to as the immunological
Select Option junctionsynapsecoupling
; it is also referred to as the SMAC. The acronym SMAC refers to the
Select Option SupraMolecular Activation ClusterSuperMolecular Activation ClusterSuperMolecular Activated Cells
.
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