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The function of MHC Class I molecules in the endogenous pathway and MHC Class II molecules in the exogenous pathway relies upon the correct assembly and loading of petite fragments into the MHC molecules and trafficking to the cell surface.

MHC Class I and MHC Class II molecules are both assembled in the
Select Option golgi apparatusendoplasmic reticulumcytosol
. Unlike MHC Class II molecules, MHC Class I molecules that are not bound to a peptide
Select Option are trafficked to the endosomeare trafficked to the cell surfaceremain in the endoplasmic reticulum
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