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A 4 y/o patient presents with recurrent sinus infections. The boy has a history of infections with pyogenic (pus-forming) bacteria. IgM levels were measured to be about 220 mg/dL (normal: 75-150 mg/dL). Patient has normal T cell and B cell levels. Below, a flow diagram is presented from the patient, showing bound soluble CD40.

Flow diagram of normal individual and the 4 y/o patient. Shown are the number of cells binding soluble CD40. Created for Copyright 2017. All rights reserved.

Based on this flow diagram, what would you suspect the patient has?


X-linked Severe Combined Immunodeficiency.


X-linked Agammaglobulinemia.


Hyper IgM Syndrome.


Hyper IgE Syndrome.

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