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Currently, the choice between positive and negative selection of TCRs is thought to hinge on the strength of self-peptide/self-MHC binding. This idea is known as the affinity hypothesis.

Based on this hypothesis, TCRs with intermediate affinity for self-peptide/MHC complexes in the cortex of the thymus would experience which type of selection listed below?


No selection (death by neglect).


Positive selection.


Agonist selection of regulatory T cells (T$_{reg}$ cells).


Negative selection.

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