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The presentation of antigens in the context of MHC does not discriminate between self and non-self antigens. Nevertheless, the immune system exhibits noticeable responses against non-self antigens but usually not against self antigens.

T cells only respond to foreign antigens because

A

T cells only recognize antigens in the context of the environment.

B

T cells only ingest and process unknown unfamiliar antigens.

C

T cells are always killed if they recognize self antigens in the context of self MHC (i.e., removed through apoptosis).

D

T cells are programmed to recognize differences between the same antigen derived from different self or foreign sources.

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