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The final stages of T cell maturation occur in the medulla of the thymus. However, there are specific signals that are required for mature T cells to exit.

From below, select the TWO choices which are required for thymocyte emigration to occur.

A

The T cell undergoes T cell receptor (TCR) signaling machinery changes, which cause it to proliferate instead of undergoing apoptosis.

B

The T cell undergoes T cell receptor signaling machinery changes, which cause it to undergo apoptosis rather than proliferation.

C

Thymocytes express NOTCH-1, allowing them to escape from the thymus after maturation.

D

Mature thymocytes express CD62P, which allows them to escape from the thymus and to home to lymph nodes.

E

Mature thymocytes express the S1P receptor (S1PR1) and CD62L, which allows them to escape from the thymus by binding to S1P (sphingosine 1-phosphate) and to home to lymph nodes (CD62L).

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