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The final stages of T cell maturation occur in the medulla of the thymus. However, there are specific signals that are required for mature T cells to exit.
From below, select the TWO choices which are required for thymocyte emigration to occur.
The T cell undergoes T cell receptor (TCR) signaling machinery changes, which cause it to proliferate instead of undergoing apoptosis.
The T cell undergoes T cell receptor signaling machinery changes, which cause it to undergo apoptosis rather than proliferation.
Thymocytes express NOTCH-1, allowing them to escape from the thymus after maturation.
Mature thymocytes express CD62P, which allows them to escape from the thymus and to home to lymph nodes.
Mature thymocytes express the S1P receptor (S1PR1) and CD62L, which allows them to escape from the thymus by binding to S1P (sphingosine 1-phosphate) and to home to lymph nodes (CD62L).