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In an experiment, the right forepaw of a developing mouse embryo is examined. The tissue and cellular structure are microscopically analyzed with histology at several developmental time points.

In the earliest time point, a population of cells located between the future digits of the paw is found to undergo growth-arrest and then subsequent cell death.

If the student concludes that the cells in the limb bud are undergoing apoptosis and not necrosis, what morphological changes will be observed in the cell?

A

Fragmentation of the cell membrane.

B

Shrinking of the cell, fragmentation of the nucleus, and blebbing of the cell membrane.

C

Rapid expansion of the cell size, followed by mechanical failure of the membrane.

D

Release of genomic DNA into the surrounding tissue.

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