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The catecholamine group of neurotransmitters are synthesized in a series of sequential enzymatic reactions as indicated in the figure.

Stanislav Kholmanskikh. Created for Copyright 2016. All rights reserved.

In this process tyrosine hydroxylase (TH) is a rate-limiting enzyme.

Metabolism of all catecholamines is accomplished by either monoaminooxidases (MAO) or catecholamine-O-methyltransferase (COMT).

Which of the following strategies will work BEST to treat a dopamine deficiency, such as the loss of dopaminergic neurons in the substantia nigra in Parkinson's Disease?


Inhibition of MAO and/or COMT enzymes.


Introduction of extra Aromatic Aminoacid Decarboxylase (AADC) using gene therapy.


Administration of L-DOPA.


Administration of Tyrosine.

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