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Multiple risk factors for the Alzheimer's Disease (AD) positively (e.g., physical exercise, environmental enrichment) or negatively (e.g., chronic stress, genetic factors) impact adult hippocampal neurogenesis (AHN). Disturbed AHN contributes to the earliest symptoms of AD, and the hippocampus is one of the first brain regions affected by the disease.

Which early symptoms of AD can be attributed to reduced AHN?

Select ALL that apply.

A

Elevated plasma cortisol.

B

Depression.

C

Formation of neurofibrillary tangles.

D

Deficit of short term memory.

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