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Epoxides are an important functional group for organic synthesis. The principal reactions of epoxides involve ring-opening reactions with nucleophiles.

When epoxides react with a strong nucleophile such as a Grignard reagent or amine, the reaction
Select Option doesdoes not
require the use of an acid catalyst. When a strong nucleophile reacts with an epoxide, it does so by attacking the
Select Option less-substitutedmore-substituted
epoxide carbon. The nucleophile will attack from the
Select Option same face asopposite face from
the epoxide oxygen.
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